What is Hyaluronic Acid?
Hyaluronic acid is a long, stringy, gel-like disaccharide (a type of sugar) composed of alternating molecules of Glucosamine and Glucuronic Acid and is responsible for the viscoelastic behaviour of Synovial Fluid ("joint oil") and the hydration and elastic strength of cartilage.
Hyaluronic acid has traditionally been derived from type II collagen sourced from Rooster comb. This type of hyaluronic acid has a very high molecular weight of up to six million Daltons (the unit of measurement for molecular weight).
This form of hyaluronic acid has been shown to be effective when injected directly into the joint but has too large a molecular weight to be effectively absorbed through the intestinal tract - if you are going to take something as an oral supplement it has to get from your intestines into the bloodstream and then into the cells of the joints where it is needed!
The hyaluronic acid used in Cortaflex HA Capsules is produced from a vegetable source and has a molecular weight of less than fifty thousand Daltons. These much smaller molecules are more easily absorbed than the larger molecule hyaluronic acid.
This means that hyaluronic acid can now be taken as a effective oral supplement for people AND animals. For joint supplements with Hyaluronic Acid for dogs, cats and horses see our animal website - www.natural-animal-health.co.uk
For people, Cortaflex HA Capsules - the power of Cortaflex with Hyaluronic Acid.
Buy Cortaflex HA capsules with hyaluronic acid
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If you are not sure about Hyaluronic Acid take a look at the scientific evidence:
Hyaluronic Acid (HA) may induce biological effects in addition to acting as a viscoelastic substance. This study suggests that HA preparations are different due to differences in biological activity resulting from MW
This meta-analysis confirmed the therapeutic efficacy and safety of intra-articular injection of hyaluronic acid for the treatment of osteoarthritis of the knee.
Viscosupplementation for knee osteoarthritis: a systematic review
Due to the rising number of patients affected by osteoarthritis (OA), appropriate management decisions for minimizing pain and improving physical function for patients with OA are important. Hyaluronic acid (HA) knee injections have become a common tool for the management of OA of the knee, and the number of randomized controlled trials on the efficacy and safety of this treatment is growing. We performed a systematic review of the five published meta-analyses, which include single- or double-blinded randomized trials performed at one center or multiple centers (Level I evidence). Within each meta-analysis, a quality assessment tool for each trial was used based on outcome measures of OA-related pain, disease severity, trial period, and mean efficacy. We analyzed and compared the data collection and qualitative analysis methods, outcomes, and conclusions presented for each meta-analysis. Although they used different strategies, each used scientifically sound methods for analysis of many of the same trials; however, each used a different measure of trial quality and heterogeneity. Despite these differences, all come to a similar conclusion that when the strictest quality tools and interpretation of heterogeneity are used, Level I evidence demonstrates that the use of HA in patients with OA results in modest improvement in validated outcomes.
Therefore, our study provides new data on the mechanism of action of these drugs, which could help to explain their clinical efficacy in OA patients
Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications
Hyaluronic acid (hyaluronan, HA) is a linear polysaccharide formed from disaccharide units containing N-acetyl-D: -glucosamine and glucuronic acid. It has a high molecular mass, usually in the order of millions of Daltons, and interesting viscoelastic properties influenced by its polymeric and polyelectrolyte characteristics. HA is present in almost all biological fluids and tissues.
Intraarticular hyaluronic acid injections were highly effective in improving resting and walking pain in patients with osteoarthritis of the knee on a first and a second treatment series. Duration of symptom control was about 6 mos, and the therapy was highly satisfactory to patients and was associated with very few local adverse events and limited use of concomitant therapeutic modalities. These data support the potential role of intraarticular hyaluronic acid as an effective long-term therapeutic option for patients with osteoarthritis of the knee.
By mitigating the activities of proinflammatory mediators and pain producing neuropeptides released by activated synovial cells, HA may improve the symptoms of OA
Hyaluronan (Hyaluronic Acid) has viscoelastic, anti-inflammatory and protective actions in joint tissues, and is being widely used for treatment of OA and RA patients. However, the mechanisms underlying the pharmacological action of Hyaluronic Acid on OA and RA have not been fully understood. In this article, we review the molecular weight-dependent, anti-inflammatory actions of HA preparations - produced in Japan - in joint tissues, and show that the molecular weight of HA, but not its concentration, is crucial for maintenance of cartilage elasticity.
In conclusion, intra-articular injections of Hyaluronic Acid is an effective choice of treatment in patients with knee osteoarthritis
Status of hyaluronan supplementation therapy in osteoarthritis
There is growing evidence that hyaluronans, the biology of which is complex, may also have structure-modifying activity. Thus, compared with currently approved nonoperative therapies for osteoarthritis, hyaluronans may also have beneficial effects on the disease process in osteoarthritis.
Viscosupplementation for osteoarthritis
Because viscosupplementation therapy is based on the concept of replenishing a normal physiological component of synovial fluid and cartilaginous tissue, exogenous administration of hyaluronic acid has the potential to have few side effects or local or systemic reactions.
Cortaflex HA Capsules - the power of Cortaflex with added Hyaluronic Acid.
Buy Cortaflex HA capsules with hyaluronic acid
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Brand new Cortaflex HA Capsules with added Hyaluronic Acid